Furosemide- and bumetanide-sensitive ion transport and volume control in primary astrocyte cultures from rat brain.

@article{Kimelberg1985FurosemideAB,
  title={Furosemide- and bumetanide-sensitive ion transport and volume control in primary astrocyte cultures from rat brain.},
  author={Harold K. Kimelberg and Maria V. Frangakis},
  journal={Brain research},
  year={1985},
  volume={361 1-2},
  pages={125-34}
}
K+ and Cl- transport using 42K+ and 36Cl- was studied in primary astrocyte cultures prepared from neonatal rat brains. A component of 42K+ uptake was sensitive to both furosemide and bumetanide with maximum inhibition being obtained at 1 and 0.01 mM concentrations of the inhibitors, respectively. Furosemide and bumetanide also markedly inhibited uptake of 36Cl-. 42K+ uptake in the presence of ouabain was also sensitive to the omission of medium Na+ and Cl-. These results suggest the existence… CONTINUE READING

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