Furosemide: A Clinical Evaluation of Its Diuretic Action

@article{Stason1966FurosemideAC,
  title={Furosemide: A Clinical Evaluation of Its Diuretic Action},
  author={William B. Stason and Paul J. Cannon and Henry O. Heinemann and John H. Laragh},
  journal={Circulation},
  year={1966},
  volume={34},
  pages={910–920}
}
The physiological effects of furosemide, a new diuretic agent chemically related to thiazide diuretics, have been evaluated in seven normal subjects and in 39 patients with edema of varied origin.The compound exhibited an unusually broad dose-response curve so that increasing diuresis could be induced with oral doses of from 40 mg once daily to 600 mg three times daily. At the higher dosages furosemide was significantly more effective than conventional thiazide diuretics and exhibited an order… 

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