Furofuran lignans display schistosomicidal and trypanocidal activities.

  title={Furofuran lignans display schistosomicidal and trypanocidal activities.},
  author={Ana C. Pereira and V R Esperandim and D Ferreira da Silva and Lizandra Guidi Magalh{\~a}es and Tha{\'i}s C. Lima and Dhammika N. P. Nanayakkara and Wilson Roberto Cunha and Jairo Kenupp Bastos and M{\'a}rcio Luis Andrade e Silva},
Parasitic diseases continue to be a major worldwide health problem, and there is an urgent need for development of therapeutic drugs. This paper describes synthesis of dehydrodiferulic acid dilactone 1 and dehydrodisinapic acid dilactone 2 furofuran lignans by oxidative coupling of ferulic and sinapic acids, respectively. Their schistosomicidal, trypanocidal, and leishmanicidal activities were evaluated in vitro against Schistosoma mansoni adult worms, trypomastigote and amastigotes forms of… Expand
4 Citations
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