Furin interacts with proMT1-MMP and integrin alphaV at specialized domains of renal cell plasma membrane.

@article{Mayer2003FurinIW,
  title={Furin interacts with proMT1-MMP and integrin alphaV at specialized domains of renal cell plasma membrane.},
  author={Ga{\'e}tan Mayer and Guy Boileau and Mo{\"i}se Bendayan},
  journal={Journal of cell science},
  year={2003},
  volume={116 Pt 9},
  pages={1763-73}
}
Matrix metalloproteinases (MMPs) and integrins are essential for cell and extracellular matrix homeostasis. Both membrane type-1 MMP (MT1-MMP) and the integrin alphaV subunit are fully activated upon cleavage at a furin recognition site. Furin is shuttled to the cell surface through the trans-Golgi network and endosomal system, and its only known role on plasma membrane consists in activation of opportunistic pathogenic entities. Here, we report findings about the interaction of furin with MT1… CONTINUE READING

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