Furin inhibition by compounds of copper and zinc.

@article{Podsiadlo2004FurinIB,
  title={Furin inhibition by compounds of copper and zinc.},
  author={Paul Podsiadlo and Tomoko Komiyama and Robert S Fuller and Ofer Blum},
  journal={The Journal of biological chemistry},
  year={2004},
  volume={279 35},
  pages={36219-27}
}
Furin, a human subtilisin-related proprotein convertase (SPC), is emerging as an important pharmaceutical target because it processes vital proteins of many aggressive pathogens. Furin inhibitors reported as yet are peptide derivatives and proteins, with the exception of andrographolides, which are natural compounds. Here we report that the small and highly stable compounds M(chelate)Cl(2) (M is copper or zinc) inhibit furin and Kex2, with Cu(TTP)Cl(2) and Zn(TTP)Cl(2) as the most efficient… CONTINUE READING

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