Furin and membrane type-1 metalloproteinase mRNA levels and activation of metalloproteinase-2 are associated with arterial remodeling.

@article{Kleijn2001FurinAM,
  title={Furin and membrane type-1 metalloproteinase mRNA levels and activation of metalloproteinase-2 are associated with arterial remodeling.},
  author={Dominique P V de Kleijn and Joost P. G. Sluijter and Jennifer Smit and Evelyn Velema and W Vachet Richard and Arjan H. Schoneveld and G. Pasterkamp and Cornelius Borst},
  journal={FEBS letters},
  year={2001},
  volume={501 1},
  pages={37-41}
}
Matrix metalloproteinase (MMP) activation is an essential feature of pathological and physiological arterial enlargement or shrinkage. Recently, furin-activated membrane type-1 MMP (MT1-MMP) was identified as the in vivo activator of MMP2 in mice. Although arterial enlargement and shrinkage are important in several pathological processes, this proprotein convertase-MT1-MMP axis has not been described during arterial remodeling. In rabbit femoral and carotid arteries, we report an increase in… CONTINUE READING

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