Furanoligularenone, an eremophilane from Ligularia fischeri, inhibits the LPS-induced production of nitric oxide and prostaglandin E2 in macrophage RAW264.7 cells.

@article{Hwang2002FuranoligularenoneAE,
  title={Furanoligularenone, an eremophilane from Ligularia fischeri, inhibits the LPS-induced production of nitric oxide and prostaglandin E2 in macrophage RAW264.7 cells.},
  author={Bang Yeon Hwang and Jeong-hyung Lee and Tae Hyeon Koo and Hang Sub Kim and Young Soo Hong and Jai Seup Ro and Kyong Soon Lee and Jung Joon Lee},
  journal={Planta medica},
  year={2002},
  volume={68 2},
  pages={101-5}
}
Furanoligularenone (1), a known eremophilane, was identified from Ligularia fischeri (Compositae) together with 3-oxo-8alpha-hydroxy-10alphaH-eremophila-1,7(11)-dien-12,8beta-olide (2) and 3-oxo-8alpha-methoxy-10alphaH-eremophila-1,7(11)-dien-12,8beta-olide (3), by its potent inhibition of LPS-induced nitric oxide (NO) and prostaglandin E2 (PGE2) production in RAW 264.7 cells. Compound 1 also suppressed the expression of iNOS and COX-2 mRNA and protein in a dose-dependent manner. Taken together… CONTINUE READING

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