Furanodiene, a natural product, inhibits breast cancer growth both in vitro and in vivo.

@article{Zhong2012FuranodieneAN,
  title={Furanodiene, a natural product, inhibits breast cancer growth both in vitro and in vivo.},
  author={Zhangfeng Zhong and Yuanye Dang and Xia Yuan and Wei Guo and Yingbo Li and Wen Tan and Jing-rong Cui and Jin-Jian Lu and Qingwen Zhang and Xiuping Chen and Yitao Wang},
  journal={Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology},
  year={2012},
  volume={30 3},
  pages={778-90}
}
PURPOSE Previous studies have reported that the Curcuma wenyujin Y.H. Chen et C. Ling extract, which has a high furanodiene content, showed anti-cancer effects in breast cancer cells in vitro. The present study was designed to evaluate the in vitro and in vivo anti-cancer activity of furanodiene. METHODS The in vitro effects of furanodiene were examined on two human breast cancer cell lines, MCF-7 and MDA-MB-231 cells. Assays of proliferation, LDH release, mitochondrial membrane potential… CONTINUE READING
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Furanodiene blocks nf-kb-dependent mmp-9 and vegf activation and inhibits cellular invasiveness and angiogenesis of breast cancer cells in vitro and in vivo

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