Fur regulates acid resistance in Shigella flexneri via RyhB and ydeP.

@article{Oglesby2005FurRA,
  title={Fur regulates acid resistance in Shigella flexneri via RyhB and ydeP.},
  author={Amanda G. Oglesby and Erin R Murphy and Vishwanath R. Iyer and Shelley M. Payne},
  journal={Molecular microbiology},
  year={2005},
  volume={58 5},
  pages={1354-67}
}
Shigella flexneri requires iron for survival, and the genes for iron uptake and homeostasis are regulated by the Fur protein. Microarrays were used to identify genes regulated by Fur and to study the physiological effects of iron availability in S. flexneri. These assays showed that the expression of genes involved in iron acquisition and acid response was induced by low-iron availability and by inactivation of fur. A fur null mutant was acid sensitive in media at pH 2.5, and acid sensitivity… CONTINUE READING