Funnels, pathways, and the energy landscape of protein folding: A synthesis

@article{Bryngelson1995FunnelsPA,
  title={Funnels, pathways, and the energy landscape of protein folding: A synthesis},
  author={Joseph D. Bryngelson and Jos{\'e} N. Onuchic and Nicholas D. Socci and Peter G. Wolynes},
  journal={Proteins: Structure},
  year={1995},
  volume={21}
}
The understanding, and even the description of protein folding is impeded by the complexity of the process. Much of this complexity can be described and understood by taking a statistical approach to the energetics of protein conformation, that is, to the energy landscape. The statistical energy landscape approach explains when and why unique behaviors, such as specific folding pathways, occur in some proteins and more generally explains the distinction between folding processes common to all… 
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