Funnels, pathways, and the energy landscape of protein folding: A synthesis

  title={Funnels, pathways, and the energy landscape of protein folding: A synthesis},
  author={J. D. Bryngelson and J. Onuchic and N. D. Socci and P. Wolynes},
  journal={Proteins: Structure},
  • J. D. Bryngelson, J. Onuchic, +1 author P. Wolynes
  • Published 1995
  • Chemistry, Physics, Medicine
  • Proteins: Structure
  • The understanding, and even the description of protein folding is impeded by the complexity of the process. Much of this complexity can be described and understood by taking a statistical approach to the energetics of protein conformation, that is, to the energy landscape. The statistical energy landscape approach explains when and why unique behaviors, such as specific folding pathways, occur in some proteins and more generally explains the distinction between folding processes common to all… CONTINUE READING
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