Funnel-web spider venom and a toxin fraction block calcium current expressed from rat brain mRNA in Xenopus oocytes.

@article{Lin1990FunnelwebSV,
  title={Funnel-web spider venom and a toxin fraction block calcium current expressed from rat brain mRNA in Xenopus oocytes.},
  author={Julie Lin and Bernardo Rudy and Rodolfo Llin{\'a}s},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1990},
  volume={87 12},
  pages={4538-42}
}
Injection of rat brain mRNA into Xenopus oocytes has been shown to induce a calcium current (ICa) that is insensitive to dihydropyridine and omega-conotoxin. We examined the effect of funnel-web spider venom on two aspects of this expressed ICa: (i) the calcium-activated chloride current [ICl(Ca)] and (ii) the currents carried by barium ions through calcium channels (IBa). In the presence of 1.8 mM extracellular calcium, ICl(Ca) tail current became detectable between -30 and -40 mV from a… CONTINUE READING

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