Fungicidal activity of miconazole against Candida spp. biofilms.

@article{Vandenbosch2010FungicidalAO,
  title={Fungicidal activity of miconazole against Candida spp. biofilms.},
  author={Davy Vandenbosch and Kevin Braeckmans and H. J. C. F. Nelis and Tom Coenye},
  journal={The Journal of antimicrobial chemotherapy},
  year={2010},
  volume={65 4},
  pages={
          694-700
        }
}

• Davy Vandenbosch, Kevin Braeckmans, +1 author Tom Coenye
• Published in The Journal of antimicrobial chemotherapy 2010
• DOI:10.1093/jac/dkq019

OBJECTIVES Although azole antifungals are considered to be fungistatic, miconazole has fungicidal activity against planktonic Candida albicans cells, presumably associated with the induction of reactive oxygen species (ROS) production. Only few data are available concerning the effect of miconazole against sessile C. albicans cells. In the present study, the fungicidal activity of miconazole against in vitro-grown mature Candida biofilms, and its relationship with the induction of ROS and ROS… CONTINUE READING

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