Fungerin, a fungal alkaloid, arrests the cell cycle in M phase by inhibition of microtubule polymerization.

Abstract

A fungal alkaloid fungerin was found to arrest the cell cycle of Jurkat cells at the G2/M phase, then to induce apoptosis. Immunoblotting showed that fungerin led to hyperphosphorylation for Cdc25C and dephosphorylation of Cdc2, indicating that the compound arrests the cell cycle at the M phase. Moreover, fungerin inhibited the polymerization of microtubule… (More)

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Cite this paper

@article{Koizumi2004FungerinAF, title={Fungerin, a fungal alkaloid, arrests the cell cycle in M phase by inhibition of microtubule polymerization.}, author={Y Koizumi and Masayoshi Arai and Hiroshi Tomoda and Satoshi O̅mura}, journal={The Journal of antibiotics}, year={2004}, volume={57 7}, pages={415-20} }