Fungal substances as modulators of NF-kappaB activation pathway.

  title={Fungal substances as modulators of NF-kappaB activation pathway.},
  author={Roumyana D. Petrova and Jamal A. Mahajna and Abraham Zeev Reznick and Solomon P. Wasser and Cvetomir M. Denchev and Eviatar Nevo},
  journal={Molecular biology reports},
  volume={34 3},
MCF7 breast cancer cell line, carrying a luciferase reporter gene under the control of nuclear factor kappa B (NF-kappaB)-responsive promoter, was established and used for the screening of fungal organic extracts for their ability to interfere with the NF-kappaB activation pathway. Twenty-eight crude fungal extracts, out of 242, were found to inhibit NF-kappaB reporter activity by more than 40%. Furthermore, positive extracts were used to evaluate their antiproliferative activity as well as… CONTINUE READING