Fungal metabolism and detoxification of fluoranthene.

  title={Fungal metabolism and detoxification of fluoranthene.},
  author={Jairaj V Pothuluri and Robert H. Heflich and Peter P Fu and Carl Cerniglia},
  journal={Applied and environmental microbiology},
  volume={58 3},
Five metabolites produced by Cunninghamella elegans from fluoranthene (FA) in biotransformation studies were investigated for mutagenic activity towards Salmonella typhimurium TA100 and TA104. Whereas FA displayed positive, dose-related mutagenic responses in both tester strains in the presence of a rat liver homogenate fraction, 3-FA-beta-glucopyranoside, 3-(8-hydroxy-FA)-beta-glucopyranoside, FA trans-2,3-dihydrodiol, and 8-hydroxy-FA trans-2,3-dihydrodiol were negative. 9-Hydroxy-FA trans-2… CONTINUE READING

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