Fungal growth inhibitory properties of new phytosphingolipid analogues

  title={Fungal growth inhibitory properties of new phytosphingolipid analogues},
  author={David Mormeneo and {\'A}ngeles Manresa and Juan Casas and Amadeu Llebaria and A. Delgado},
  journal={Journal of Applied Microbiology},
Aims:  To study the growth inhibitory properties of a series of phytosphingosine (PHS) and phytoceramide (PHC) analogues. 

Synthesis and Biological Evaluation of Antifungal Activities of Novel 1,2‐trans Glycosphingolipids

The preliminary study indicated that the sort of sugar moiety of GSLs affected their antifungal activities and selectivities towards the three Candida species, and the permeability might not be the sole parameter affecting their antIFungal properties as presumed before.

Fungicidal activity of truncated analogues of dihydrosphingosine.

Aziridine ring opening for the synthesis of sphingolipid analogues: inhibitors of sphingolipid-metabolizing enzymes.

A library of sphingolipid analogues is designed and tested as inhibitors against mammalian and fungal sphingorothioates, phosphates, and amines to afford compounds having different lipid backbones and substituents representative of the naturally occurring sphingoled families.

A Practical Access to 1,2‐Diaminophytosphingolipids

A practical approach to the synthesis of phytosphingolipids containing the 1,2-diamino framework is described. The methodology relies on the regioselective ring-opening of phytosphingosine-derived

New strategic insights into managing fungal biofilms

The antifungal properties of myriocin, fulvic acid, and acetylcholine are discussed in light of their already known anti-inflammatory activity and as candidate dual action therapeutics to treat opportunistic fungal infections.

Comparative evaluation of flexural strength and depth of penetration following dentin pretreatment with proanthocyanidin and phytosphingosine

PHS may serve as a promising alternative to PAC when applied over demineralized dentin after surface pretreatment with phytosphingosine and proanthocyanidin.



Antifungal activity of bifunctional sphingolipids. Intramolecular synergism within long-chain alpha,omega-bis-aminoalcohols.

The in vitro antifungal activity of a series of alpha,omega-bifunctionalized aminoalcohols against Candida glabrata was measured. The dimeric bi-functionalized lipids exhibited activity about

Fungal sphingolipids as targets for the development of selective antifungal therapeutics.

Sphingolipids are essential membrane components, present in all eukaryotic cells, but structurally distinct in mammalian and fungal cells. Therefore, they represent an attractive new target for the

In vitro activity of phytosphingosines against Malassezia furfur and Candida albicans.

The aim of this study was to investigate the in vitro activity of different phytosphingosine preparations against Malassezia furfur, and, in comparison, against the common facultative pathogenic yeast Candida albicans.

Sphingolipids-Their Metabolic Pathways and the Pathobiochemistry of Neurodegenerative Diseases.

The investigation of the metabolism of this class of compounds gives insight into human diseases, novel signal transduction processes, and the epidermal water permeability barrier.

Antifungal alkyl amino alcohols from the tropical marine sponge Haliclona n. sp.

Three new amino alcohols presumably deriving from L-alanine were isolated from the tropical marine sponge Haliclona n. sp. and characterized by 2D NMR, while a fourth amino alcohol was characterized

IPC synthase as a useful target for antifungal drugs.

Current progress in the development of IPC synthase inhibitors with antifungal activities are reviewed, and structure-activity relationships (SAR), physicochemical and structural properties, and synthetic methodology for chemical modification are presented.

Phytosphingosine as a Specific Inhibitor of Growth and Nutrient Import in Saccharomyces cerevisiae *

This study used a combination of pharmacological and genetic approaches to determine which endogenous sphingolipid is the likely mediator of growth inhibition and determined the specificity of PHS.

Induction of Apoptosis by Sphingoid Long-Chain Bases in Aspergillus nidulans

DHS and PHS induce a type of apoptosis in A. nidulans most similar to the caspase-independent apoptosis observed in mammalian systems, which is demonstrated to be independent of metacaspase function but requires mitochondrial function.

Modulation of the ceramide level, a novel therapeutic concept?

An improved understanding of SMase-dependent signaling may afford relevant insights into the pathogenesis of diseases and provide novel strategies and selective targets for a therapeutic intervention e.g. in cancer, cardiovascular and neurodegenerative diseases, HIV and septic shock.