Fungal cytochrome P450 sterol 14α-demethylase (CYP51) and azole resistance in plant and human pathogens

@article{Becher2012FungalCP,
  title={Fungal cytochrome P450 sterol 14$\alpha$-demethylase (CYP51) and azole resistance in plant and human pathogens},
  author={Rayko Becher and Stefan G R Wirsel},
  journal={Applied Microbiology and Biotechnology},
  year={2012},
  volume={95},
  pages={825-840}
}
Azoles have been applied widely to combat pathogenic fungi in medicine and agriculture and, consequently, loss of efficacy has occurred in populations of some species. Often, but not always, resistance was found to result from amino acid substitutions in the molecular target of azoles, 14α-sterol demethylase (CYP51 syn. ERG11). This review summarizes CYP51 function, evolution, and structure. Furthermore, we compare the occurrence and contribution of CYP51 substitutions to azole resistance in… Expand
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