Fungal beta-tubulin, expressed as a fusion protein, binds benzimidazole and phenylcarbamate fungicides.

@article{Hollomon1998FungalBE,
  title={Fungal beta-tubulin, expressed as a fusion protein, binds benzimidazole and phenylcarbamate fungicides.},
  author={Dr. Derek W. Hollomon and Jenny A Butters and H. L. Barker and Leslie J Hall},
  journal={Antimicrobial agents and chemotherapy},
  year={1998},
  volume={42 9},
  pages={2171-3}
}
Benzimidazoles are important antitubulin agents used in veterinary medicine and plant disease control. Resistance is a practical problem correlated with single amino acid changes in beta-tubulin and is often linked to greater sensitivity to phenylcarbamates. This negative cross-resistance creates opportunities for durable antiresistance strategies. Attempts to understand the molecular basis of benzimidazole resistance have been hampered by the inability to purify tubulin from filamentous fungi… CONTINUE READING