Fungal Mimicry of a Mammalian Aminopeptidase Disables Innate Immunity and Promotes Pathogenicity.

@article{Sterkel2016FungalMO,
  title={Fungal Mimicry of a Mammalian Aminopeptidase Disables Innate Immunity and Promotes Pathogenicity.},
  author={Alana Sterkel and Jenna L Lorenzini and J Scott Fites and Kavitha Subramanian Vignesh and Thomas D. Sullivan and Marcel Wuthrich and Tristan Brandhorst and Nydiaris Hern{\'a}ndez-Santos and George S Deepe and Bruce S Klein},
  journal={Cell host & microbe},
  year={2016},
  volume={19 3},
  pages={361-74}
}
Systemic fungal infections trigger marked immune-regulatory disturbances, but the mechanisms are poorly understood. We report that the pathogenic yeast of Blastomyces dermatitidis elaborates dipeptidyl-peptidase IVA (DppIVA), a close mimic of the mammalian ectopeptidase CD26, which modulates critical aspects of hematopoiesis. We show that, like the mammalian enzyme, fungal DppIVA cleaved C-C chemokines and GM-CSF. Yeast producing DppIVA crippled the recruitment and differentiation of monocytes… CONTINUE READING
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