Fungal Metabolites, Sorbicillinoid Polyketides and Their Effects on the Activation of Peroxisome Proliferator-activated Receptor γ

@article{Lee2005FungalMS,
  title={Fungal Metabolites, Sorbicillinoid Polyketides and Their Effects on the Activation of Peroxisome Proliferator-activated Receptor γ},
  author={Dongho Lee and Jeong-hyung Lee and Xing Fu Cai and Jin Shin and Kyeong Sook Lee and Young-Soo Hong and Jung Joon Lee},
  journal={The Journal of Antibiotics},
  year={2005},
  volume={58},
  pages={615-620}
}
A new sorbicillinoid polyketide, dihydrotrichodimerol (2), along with known trichodimerol (1), and rezishanones C (3) and D (4) were isolated by bioassay-guided fractionation from an unidentified fungal strain. Dihydrotrichodimerol (2) specifically activated peroxisome proliferator-activated receptor γ with an ED50 value of 80 ng/ml as measured by a transactivation assay using a chimeric hPPAR/GAL4 system without affecting peroxisome proliferator-activated receptors α and δ. On the other hand… CONTINUE READING