Fungal Glucosylceramides: From Structural Components to Biologically Active Targets of New Antimicrobials

@inproceedings{Nimrichter2011FungalGF,
  title={Fungal Glucosylceramides: From Structural Components to Biologically Active Targets of New Antimicrobials},
  author={Leonardo Nimrichter and Marcio Lourenço Rodrigues},
  booktitle={Front. Microbio.},
  year={2011}
}
The first work reporting synthesis of glucosylceramide (cerebrin, GlcCer) by yeasts was published in 1930. During approximately 70 years members of this class of glycosphingolipids (GSL) were considered merely structural components of plasma membrane in fungi. However, in the last decade GlcCer was reported to be involved with fungal growth, differentiation, virulence, immunogenicity, and lipid raft architecture in at least two human pathogens. Fungal GlcCer are structurally distinct from their… CONTINUE READING
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