Fungal Biotransformation of Tetracycline Antibiotics.

  title={Fungal Biotransformation of Tetracycline Antibiotics.},
  author={Zhuo Bin Shang and Angela A. Salim and Zeinab G. Khalil and Paul V Bernhardt and Robert J Capon},
  journal={The Journal of organic chemistry},
  volume={81 15},
The commercial antibiotics tetracycline (3), minocycline (4), chlortetracycline (5), oxytetracycline (6), and doxycycline (7) were biotransformed by a marine-derived fungus Paecilomyces sp. to yield seco-cyclines A-H (9-14, 18 and 19) and hemi-cyclines A-E (20-24). Structures were assigned by detailed spectroscopic analysis, and in the case of 10 X-ray crystallography. Parallel mechanisms account for substrate-product specificity, where 3-5 yield seco-cyclines and 6 and 7 yield hemi-cyclines… CONTINUE READING
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