Fungal Biotransformation of Tetracycline Antibiotics.

@article{Shang2016FungalBO,
  title={Fungal Biotransformation of Tetracycline Antibiotics.},
  author={Zhuo Bin Shang and Angela A. Salim and Zeinab G. Khalil and Paul V Bernhardt and Robert J Capon},
  journal={The Journal of organic chemistry},
  year={2016},
  volume={81 15},
  pages={
          6186-94
        }
}
The commercial antibiotics tetracycline (3), minocycline (4), chlortetracycline (5), oxytetracycline (6), and doxycycline (7) were biotransformed by a marine-derived fungus Paecilomyces sp. to yield seco-cyclines A-H (9-14, 18 and 19) and hemi-cyclines A-E (20-24). Structures were assigned by detailed spectroscopic analysis, and in the case of 10 X-ray crystallography. Parallel mechanisms account for substrate-product specificity, where 3-5 yield seco-cyclines and 6 and 7 yield hemi-cyclines… CONTINUE READING
Recent Discussions
This paper has been referenced on Twitter 5 times over the past 90 days. VIEW TWEETS