Fungal Adenylyl Cyclase Integrates CO2 Sensing with cAMP Signaling and Virulence

@article{Klengel2005FungalAC,
  title={Fungal Adenylyl Cyclase Integrates CO2 Sensing with cAMP Signaling and Virulence},
  author={Torsten Klengel and Wei-jun Liang and James Chaloupka and Claudia Ruoff and Klaus Schröppel and Julian R. Naglik and Sabine E. Eckert and Estelle Gewiss Mogensen and Ken Haynes and Mick F. Tuite and Lonny R. Levin and Jochen Buck and Fritz A. Mühlschlegel},
  journal={Current Biology},
  year={2005},
  volume={15}
}
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361 Citations

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    TLDR
    It is discovered that G-actin plays a regulatory role, rendering cAMP synthesis responsive to actin dynamics, shed new lights on the mechanisms that regulate cAMP-mediated responses in fungi.
    Bacterial peptidoglycan triggers Candida albicans hyphal growth by directly activating the adenylyl cyclase Cyr1p.
    Cryptococcus neoformans Senses CO2 through the Carbonic Anhydrase Can2 and the Adenylyl Cyclase Cac1
    TLDR
    The data reveal Can2 to be the main carbonic anhydrase and suggest a physiological role for bicarbonate during C. neoformans growth, which is optimal at physiological pH.
    A multi‐protein complex controls cAMP signalling and filamentation in the fungal pathogen Candida albicans
    TLDR
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    TLDR
    The regulation of the yeast-hypha transition, virulence, and white-opaque switching through the cAMP/PKA pathway in the closely related species C. albicans and C. tropicalis is discussed.
    cAMP‐independent signal pathways stimulate hyphal morphogenesis in Candida albicans
    TLDR
    Mutational analysis showed that induction of hyphae in a pseudorevertant strain was independent of RAS1, but was dependent on the EFG1 transcription factor that acts downstream of protein kinase A, indicating that cAMP‐independent signals contribute to the induction ofhyphal responses.
    Retigeric Acid B Attenuates the Virulence of Candida albicans via Inhibiting Adenylyl Cyclase Activity Targeted by Enhanced Farnesol Production
    TLDR
    It is shown that RAB stimulates farnesol production that directly inhibits the Cdc35 activity, reducing the synthesis of cAMP and thereby causing the disruption of the morphologic transition and attenuating the virulence of C. albicans.
    CO2 Acts as a Signalling Molecule in Populations of the Fungal Pathogen Candida albicans
    TLDR
    The results reveal the existence of a gaseous Candida signalling pathway and its molecular mechanism and provide insights into an evolutionary conserved CO2-signalling system, suggesting that metabolic CO2 sensing may be important for initial colonisation and epithelial invasion.
    CO 2 Acts as a Signalling Molecule in Populations of the Fungal Pathogen Candida albicans
    TLDR
    It is shown that within such biomasses, fungal metabolically generated CO2 acts as a communication molecule promoting the switch from yeast to filamentous growth essential for C. albicans pathology.
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