Fundamentals of planarian regeneration.

@article{Reddien2004FundamentalsOP,
  title={Fundamentals of planarian regeneration.},
  author={Peter W. Reddien and Alejandro S{\'a}nchez Alvarado},
  journal={Annual review of cell and developmental biology},
  year={2004},
  volume={20},
  pages={
          725-57
        }
}
The principles underlying regeneration in planarians have been explored for over 100 years through surgical manipulations and cellular observations. Planarian regeneration involves the generation of new tissue at the wound site via cell proliferation (blastema formation), and the remodeling of pre-existing tissues to restore symmetry and proportion (morphallaxis). Because blastemas do not replace all tissues following most types of injuries, both blastema formation and morphallaxis are needed… 

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Examining Procotyla fluviatilis, a planarian with restricted ability to replace missing tissues, is examined, finding that Wnt signalling is aberrantly activated in regeneration-deficient tissues and manipulating a single signalling pathway can reverse the evolutionary loss of regenerative potential.
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TLDR
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TLDR
The objective of this article is to present a molecular strategy to identify and functionally manipulate genes involved in the process of blastema‐derived regeneration and define a series of useful molecular templates that may help unravel the more complex epigenetic processes of vertebrate regeneration.
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TLDR
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