Fundamentals of host immune response against Brucella abortus: what the mouse model has revealed about control of infection.

@article{Baldwin2002FundamentalsOH,
  title={Fundamentals of host immune response against Brucella abortus: what the mouse model has revealed about control of infection.},
  author={Cynthia L. Baldwin and Michelle A Parent},
  journal={Veterinary microbiology},
  year={2002},
  volume={90 1-4},
  pages={367-82}
}
The studies reviewed here evaluated the role cellular immune system components play in control of brucellosis by conducting comparative studies with brucella-resistant C57BL/10 or C57BL/6 mice and susceptible BALB/c mice. We have shown by both in vitro and in vivo studies that activation of macrophages with interferon-gamma (IFN-gamma) is an important factor for control of infection with B. abortus in the mouse model and that the mechanism of anti-brucella activity largely involved reactive… CONTINUE READING
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