Fundamentally Different Logic of Gene Regulation in Eukaryotes and Prokaryotes

@article{Struhl1999FundamentallyDL,
  title={Fundamentally Different Logic of Gene Regulation in Eukaryotes and Prokaryotes},
  author={Kevin Struhl},
  journal={Cell},
  year={1999},
  volume={98},
  pages={1-4}
}
the promoter sequences (which is related, but not equivalent to, DNA binding affinity). In vivo, an isolated promoter region is sufficient to initiate transcription at a rate comparable to that achieved in vitro. Moreover, the strongest promoters initiate transcription at the maximal rate, which is ultimately limited by the rate at which RNA polymerase elongates and clears the promoter, thereby permitting another round of initiation. In other words, there is no inherent restriction on the… CONTINUE READING
180 Citations
4 References
Similar Papers

Citations

Publications citing this paper.
Showing 1-10 of 180 extracted citations

References

Publications referenced by this paper.
Showing 1-4 of 4 references

In these and other large-scale repression

  • In these and other large-scale repression
  • 1999
1 Excerpt

Nature

  • A John, S Workman
  • Nature
  • 1998

In worms, SDC-2 targets a specialized complex M

  • S E Rundlett, A A Carmen, N Suka, B M Turner, Grunstein
  • Nature
  • 1996

Nucleic Acids Res

  • K Of Dosage Compensation Proteins To Hermaphrodite X, J C Wang
  • Nucleic Acids Res
  • 1996

Similar Papers

Loading similar papers…