Fundamental patterns underlying gene expression profiles: simplicity from complexity.

  title={Fundamental patterns underlying gene expression profiles: simplicity from complexity.},
  author={Neal S. Holter and Madhusmita Mitra and Amos Maritan and Marek Cieplak and Jayanth R. Banavar and Nina V. Fedoroff},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  volume={97 15},
Analysis of previously published sets of DNA microarray gene expression data by singular value decomposition has uncovered underlying patterns or "characteristic modes" in their temporal profiles. These patterns contribute unequally to the structure of the expression profiles. Moreover, the essential features of a given set of expression profiles are captured using just a small number of characteristic modes. This leads to the striking conclusion that the transcriptional response of a genome is… CONTINUE READING
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