Fundamental link between folding states and functional states of proteins.

@article{Kalbitzer2009FundamentalLB,
  title={Fundamental link between folding states and functional states of proteins.},
  author={Hans Robert Kalbitzer and Michael T. Spoerner and Petra Ganser and Constantin Hozsa and Werner Kremer},
  journal={Journal of the American Chemical Society},
  year={2009},
  volume={131 46},
  pages={
          16714-9
        }
}
Folding and function of proteins are two aspects of proteins which are usually considered as basically unrelated phenomena that are optimized by evolution independently. From the funnel model of folding/unfolding and the associated energy landscape, we infer the paradigm that the minimum number of folding intermediates is determined by the number of all functional states of a protein ("essential" folding intermediates). Here, we demonstrate the supposed fundamental link using the Ras protein… Expand
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