Fundamental differences between the nucleic acid chaperone activities of HIV-1 nucleocapsid protein and Gag or Gag-derived proteins: biological implications.

@article{Wu2010FundamentalDB,
  title={Fundamental differences between the nucleic acid chaperone activities of HIV-1 nucleocapsid protein and Gag or Gag-derived proteins: biological implications.},
  author={Tiyun Wu and Siddhartha A K Datta and Mithun Mitra and Robert J. Gorelick and Alan Rein and Judith G Levin},
  journal={Virology},
  year={2010},
  volume={405 2},
  pages={
          556-67
        }
}
The HIV-1 Gag polyprotein precursor has multiple domains including nucleocapsid (NC). Although mature NC and NC embedded in Gag are nucleic acid chaperones (proteins that remodel nucleic acid structure), few studies include detailed analysis of the chaperone activity of partially processed Gag proteins and comparison with NC and Gag. Here we address this issue by using a reconstituted minus-strand transfer system. NC and NC-containing Gag proteins exhibited annealing and duplex destabilizing… CONTINUE READING
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