Fundamental Limits to Position Determination by Concentration Gradients

@article{Tostevin2007FundamentalLT,
  title={Fundamental Limits to Position Determination by Concentration Gradients},
  author={Filipe Tostevin and Pieter Rein ten Wolde and Martin Howard},
  journal={PLoS Computational Biology},
  year={2007},
  volume={3},
  pages={1 - 47}
}
Position determination in biological systems is often achieved through protein concentration gradients. Measuring the local concentration of such a protein with a spatially varying distribution allows the measurement of position within the system. For these systems to work effectively, position determination must be robust to noise. Here, we calculate fundamental limits to the precision of position determination by concentration gradients due to unavoidable biochemical noise perturbing the… CONTINUE READING
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