Fundamental Limits to Collective Concentration Sensing in Cell Populations.

@article{Fancher2016FundamentalLT,
  title={Fundamental Limits to Collective Concentration Sensing in Cell Populations.},
  author={Sean Fancher and Andrew Mugler},
  journal={Physical review letters},
  year={2016},
  volume={118 7},
  pages={
          078101
        }
}
The precision of concentration sensing is improved when cells communicate. Here we derive the physical limits to concentration sensing for cells that communicate over short distances by directly exchanging small molecules (juxtacrine signaling), or over longer distances by secreting and sensing a diffusive messenger molecule (autocrine signaling). In the latter case, we find that the optimal cell spacing can be large, due to a trade-off between maintaining communication strength and reducing… 

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