Fundamental Flaws of Hormesis for Public Health Decisions

@article{Thayer2005FundamentalFO,
  title={Fundamental Flaws of Hormesis for Public Health Decisions},
  author={K. Thayer and R. Melnick and Kathy Burns and Devra Davis and J. Huff},
  journal={Environmental Health Perspectives},
  year={2005},
  volume={113},
  pages={1271 - 1276}
}
Hormesis (defined operationally as low-dose stimulation, high-dose inhibition) is often used to promote the notion that while high-level exposures to toxic chemicals could be detrimental to human health, low-level exposures would be beneficial. Some proponents claim hormesis is an adaptive, generalizable phenomenon and argue that the default assumption for risk assessments should be that toxic chemicals induce stimulatory (i.e., “beneficial”) effects at low exposures. In many cases… Expand
120 Citations
The importance of hormesis to public health.
  • 97
  • PDF
The importance of hormesis to public health.
  • 50
Hormesis and Its Place in Nonmonotonic Dose–Response Relationships: Some Scientific Reality Checks
  • P. Mushak
  • Psychology, Medicine
  • Environmental health perspectives
  • 2007
  • 61
  • Highly Influenced
The hormesis concept and risk assessment: are there unique ethical and policy considerations?
  • 12
Defining Hormesis: Evaluation of a Complex Concentration Response Phenomenon
  • 121
  • PDF
Hormesis: why it is important to toxicology and toxicologists.
  • 382
Hormesis: why it is important to toxicology and toxicologists.
  • E. Calabrese
  • Medicine
  • Environmental toxicology and chemistry
  • 2008
  • 157
  • PDF
Hormesis and toxic torts
  • G. Marchant
  • Economics, Medicine
  • Human & experimental toxicology
  • 2008
  • 2
...
1
2
3
4
5
...

References

SHOWING 1-10 OF 111 REFERENCES
Defining hormesis
  • 350
  • PDF
Hormesis: the dose-response revolution.
  • 516
  • Highly Influential
Defining hormesis. Commentary. Authors reply
  • 335
Applications of hormesis in toxicology, risk assessment and chemotherapeutics.
  • 157
The frequency of U-shaped dose responses in the toxicological literature.
  • E. Calabrese, L. Baldwin
  • Psychology, Medicine
  • Toxicological sciences : an official journal of the Society of Toxicology
  • 2001
  • 375
  • Highly Influential
  • PDF
Radiation-induced versus endogenous DNA damage: possible effect of inducible protective responses in mitigating endogenous damage
  • 162
Peptides and Hormesis
  • 37
  • Highly Influential
Test of the linear no-threshold theory of radiation-induced cancer
  • 2
...
1
2
3
4
5
...