Fundamental Difference in the Content of High-Mannose Carbohydrate in the HIV-1 and HIV-2 Lineages

  title={Fundamental Difference in the Content of High-Mannose Carbohydrate in the HIV-1 and HIV-2 Lineages},
  author={Elizabeth Stansell and R. Desrosiers},
  journal={Journal of Virology},
  pages={8998 - 9009}
  • Elizabeth Stansell, R. Desrosiers
  • Published 2010
  • Biology, Medicine
  • Journal of Virology
  • ABSTRACT The virus-encoded envelope proteins of human immunodeficiency virus (HIV) and simian immunodeficiency virus (SIV) typically contain 26 to 30 sites for N-linked carbohydrate attachment. N-linked carbohydrate can be of three major types: high mannose, complex, or hybrid. The lectin proteins from Galanthus nivalis (GNA) and Hippeastrum hybrid (HHA), which specifically bind high-mannose carbohydrate, were found to potently inhibit the replication of a pathogenic cloned SIV from rhesus… CONTINUE READING
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