Functions of yeast helicase Ssl2p that are essential for viability are also involved in protection from the toxicity of adriamycin.

@article{Furuchi2004FunctionsOY,
  title={Functions of yeast helicase Ssl2p that are essential for viability are also involved in protection from the toxicity of adriamycin.},
  author={Takemitsu Furuchi and Tsutomu Takahashi and Shogo Tanaka and Katsushi Nitta and Akira Naganuma},
  journal={Nucleic acids research},
  year={2004},
  volume={32 8},
  pages={2578-85}
}
We have found that, in the yeast Saccharomyces cerevisiae, overexpression of the DNA helicase Ssl2p confers resistance to adriamycin. Ssl2p is involved, as a subunit of the basic transcription factor TFIIH, in the initiation of transcription and in nucleotide-excision repair (NER), and this helicase is essential for the survival of yeast cells. An examination of the relationship between the known functions of Ssl2p and adriamycin resistance indicated that overexpression of Ssl2p caused little… CONTINUE READING

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