Functions of tropomyosin's periodic repeats.

@article{HitchcockDeGregori2002FunctionsOT,
  title={Functions of tropomyosin's periodic repeats.},
  author={Sarah E. Hitchcock-DeGregori and Yuhua Song and Norma J. Greenfield},
  journal={Biochemistry},
  year={2002},
  volume={41 50},
  pages={15036-44}
}
Tropomyosin binds along actin filaments and regulates actin-myosin interaction in muscle and nonmuscle cells. Seven periodic amino acid repeats are proposed to correspond to actin binding sites, and the middle periods are important for cooperative activation of actin by myosin. The functional contributions of individual periods were studied in mutants in which periods 2-6 were individually deleted from rat striated muscle alphaalpha-tropomyosin or replaced with a leucine zipper sequence… CONTINUE READING