Functions of the unique N-terminal region of glycoprotein E in the pathogenesis of varicella-zoster virus infection.

@article{Berarducci2010FunctionsOT,
  title={Functions of the unique N-terminal region of glycoprotein E in the pathogenesis of varicella-zoster virus infection.},
  author={Barbara Berarducci and Jaya Rajamani and Leigh Zerboni and Xibing Che and Marvin H Sommer and Ann Margaret Arvin},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2010},
  volume={107 1},
  pages={282-7}
}
Varicella-zoster virus (VZV) is an alphaherpesvirus that infects skin, lymphocytes, and sensory ganglia. VZV glycoprotein E (gE) has a unique N-terminal region (aa1-188), which is required for replication and includes domains involved in secondary envelopment, efficient cell-cell spread, and skin infection in vivo. The nonconserved N-terminal region also mediates binding to the insulin-degrading enzyme (IDE), which is proposed to be a VZV receptor. Using viral mutagenesis to make the… CONTINUE READING

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