Functions of the adaptor protein p66Shc in solid tumors

Abstract

p66Shc is a 66 kDa Src homology 2 domain containing (Shc) adaptor protein homolog. Previous studies have demonstrated that p66Shc is a proapoptotic protein involved in the cellular response to oxidative stress and in regulating mammalian lifespan. However, accumulating evidence also indicates its critical role in solid tumor progression. The expression of… (More)
DOI: 10.1007/s11515-015-1376-9

Topics

2 Figures and Tables

Cite this paper

@article{Sun2015FunctionsOT, title={Functions of the adaptor protein p66Shc in solid tumors}, author={Yanan Sun and Jie Yang and Zhenyi Ma}, journal={Frontiers in Biology}, year={2015}, volume={10}, pages={487-494} }