Functions of the ORF9-to-ORF12 gene cluster in varicella-zoster virus replication and in the pathogenesis of skin infection.

@article{Che2008FunctionsOT,
  title={Functions of the ORF9-to-ORF12 gene cluster in varicella-zoster virus replication and in the pathogenesis of skin infection.},
  author={Xibing Che and Mike Reichelt and Marvin H. Sommer and J. K. Rajamani and Leigh Zerboni and Ann M. Arvin},
  journal={Journal of virology},
  year={2008},
  volume={82 12},
  pages={
          5825-34
        }
}
  • Xibing Che, Mike Reichelt, +3 authors Ann M. Arvin
  • Published in Journal of virology 2008
  • Biology, Medicine
  • The gene cluster composed of varicella-zoster virus (VZV) open reading frame 9 (ORF9) to ORF12 encodes four putative tegument proteins and is highly conserved in most alphaherpesviruses. In these experiments, the genes within this cluster were deleted from the VZV parent Oka (POKA) individually or in combination, and the consequences for VZV replication were evaluated with cultured cells in vitro and with human skin xenografts in SCID mice in vivo. As has been reported for ORF10, ORF11 and… CONTINUE READING

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    Citations

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    ORF9p phosphorylation by ORF47p is crucial for the formation and egress of varicella-zoster virus viral particles.

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    Deletion of the ORF9p acidic cluster impairs the nuclear egress of varicella-zoster virus capsids.

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