Functions of the ON and OFF channels of the visual system

@article{Schiller1986FunctionsOT,
  title={Functions of the ON and OFF channels of the visual system},
  author={Peter H. Schiller and Julie H. Sandell and John H.R. Maunsell},
  journal={Nature},
  year={1986},
  volume={322},
  pages={824-825}
}
In the mammalian eye, the ON-centre and OFF-centre retinal ganglion cells form two major pathways projecting to central visual structures from the retina. These two pathways originate at the bipolar cell level: one class of bipolar cells becomes hyperpolarized in response to light, as do all photoreceptor cells, and the other class becomes depolarized on exposure to light, thereby inverting the receptor signal. It has recently become possible to examine the functional role of the ON-pathway in… Expand
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References

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TLDR
The results suggest that the ON and OFF systems do not interact significantly at the level of the LGN, but do so in the striate cortex, and the centre-surround organization of OFF-centre cells was unaffected. Expand
Response properties of cells in rabbit's lateral geniculate nucleus during reversible blockade of retinal on-center channel.
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Receptive field properties in the cat's lateral geniculate nucleus in the absence of on-center retinal input
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TLDR
Investigation of how lateral geniculate neurons and retinal ganglion cells are affected when a drug is applied to the retina that inactivates on-bipolar cells in the mudpuppy found that the surrounds of many off-center cells could still be excited by light stimuli; thus, despite the probable inactivation of on- bipolar cells, not all on- responses in the LGN were abolished. Expand
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TLDR
Overall responsiveness in the injected eye was severely reduced, and responses to the onset of stationary light stimuli were almost entirely abolished, indicating that the on and off pathways both contribute (directly or indirectly) to the responses of most cells in area 17. Expand
Morphology and mosaic of on- and off-beta cells in the cat retina and some functional considerations
TLDR
The mosaic of beta cells imposes some constraints and permits some predictions to be made with respect to the cat’s visual discrimination. Expand
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In the ferret, there is a sublamination of the retinal input to lateral geniculate nucleus laminae A and A1 and the function is investigated by making microelectrode recordings and it is found that each sublamina consists of geniculated neurons of a single center type. Expand
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TLDR
In the mink, the principal layers innervated by the contralateral eye and the ipsilateral eye are each split into two adjacent leaflets, and it is reported here that the anterior leaflet of each pair contains ON-centre neurones and the posterior leaflets OFF-centres neurones. Expand
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TLDR
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TLDR
Intracacellular electrophysiological recordings from the perfused retina-eyecup preparation of the mud-puppy showed that the addition of 2-amino-4-phosphonobutyric acid to the bathing medium blocked all responses in the ON channel but left intact the OFF responses including OFF ganglion cell discharge. Expand
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