Functions of the DNA dependent protein kinase.

  title={Functions of the DNA dependent protein kinase.},
  author={Shunqian Jin and Shinichi Inoue and David T. Weaver},
  journal={Cancer surveys},
The DNA dependent protein kinase (DNA-PK) is a trimeric nuclear complex consisting of a large protein kinase and the Ku heterodimer that regulates kinase activity by its association with DNA. Recent findings have shown structural similarities between DNA-PK and a family of lipid and putative protein kinases (PIK family). DNA-PK is one of the PIK members known to be a protein kinase with clearly identified effector subunits. A broad range of observations link DNA-PK to dual roles in double… CONTINUE READING