Functions of the APP gene family in the nervous system: insights from mouse models

@article{Aydin2011FunctionsOT,
  title={Functions of the APP gene family in the nervous system: insights from mouse models},
  author={Dorothee Aydin and Sascha W. Weyer and Ulrike C M{\"u}ller},
  journal={Experimental Brain Research},
  year={2011},
  volume={217},
  pages={423-434}
}
The amyloid precursor protein (APP) plays a key role in the pathogenesis of Alzheimer’s disease (AD), as proteolytical cleavage of APP gives rise to the β-amyloid peptide which is deposited in the brains of Alzheimer patients. During the past years, intense research efforts have been directed at elucidating the physiological function(s) of APP and the question of whether a perturbation of these functions contributes to AD pathogenesis. Indeed, a growing body of evidence has accumulated… CONTINUE READING
Related Discussions
This paper has been referenced on Twitter 1 time. VIEW TWEETS

From This Paper

Figures, tables, and topics from this paper.

Citations

Publications citing this paper.
Showing 1-10 of 50 extracted citations

Novel GαS-protein signaling associated with membrane-tethered amyloid precursor protein intracellular domain.

The Journal of neuroscience : the official journal of the Society for Neuroscience • 2012
View 5 Excerpts
Highly Influenced

References

Publications referenced by this paper.
Showing 1-10 of 95 references

Presynaptic and postsynaptic interaction of the amyloid precursor protein promotes peripheral and central synaptogenesis.

The Journal of neuroscience : the official journal of the Society for Neuroscience • 2009
View 9 Excerpts
Highly Influenced

Expression of a ubiquitous , crossreactive homologue of the mouse betaamyloid precursor protein ( APP )

HH Slunt, G Thinakaran, +3 authors SS Sisodia
J Biol Chem • 1994
View 10 Excerpts
Highly Influenced

Amyloid precursor protein regulates Cav1.2 L-type calcium channel levels and function to influence GABAergic short-term plasticity.

The Journal of neuroscience : the official journal of the Society for Neuroscience • 2009
View 3 Excerpts
Highly Influenced

Similar Papers

Loading similar papers…