Functions of outer membrane receptors in mitochondrial protein import.

@article{Endo2002FunctionsOO,
  title={Functions of outer membrane receptors in mitochondrial protein import.},
  author={Toshiya Endo and Daisuke Kohda},
  journal={Biochimica et biophysica acta},
  year={2002},
  volume={1592 1},
  pages={3-14}
}
Most mitochondrial proteins are synthesized in the cytosol as precursor proteins and are imported into mitochondria. The targeting signals for mitochondria are encoded in the presequences or in the mature parts of the precursor proteins, and are decoded by the receptor sites in the translocator complex in the mitochondrial outer membrane. The recently determined NMR structure of the general import receptor Tom20 in a complex with a presequence peptide reveals that, although the amphiphilicity… CONTINUE READING