Functions of bromodomain-containing proteins and their roles in homeostasis and cancer

@article{Fujisawa2017FunctionsOB,
  title={Functions of bromodomain-containing proteins and their roles in homeostasis and cancer},
  author={Takao Fujisawa and Panagis Filippakopoulos},
  journal={Nature Reviews Molecular Cell Biology},
  year={2017},
  volume={18},
  pages={246-262}
}
Bromodomains (BRDs) are evolutionarily conserved protein–protein interaction modules that are found in a wide range of proteins with diverse catalytic and scaffolding functions and are present in most tissues. BRDs selectively recognize and bind to acetylated Lys residues — particularly in histones — and thereby have important roles in the regulation of gene expression. BRD-containing proteins are frequently dysregulated in cancer, they participate in gene fusions that generate diverse… CONTINUE READING
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