Functions of autophagy in normal and diseased liver

@article{Czaja2013FunctionsOA,
  title={Functions of autophagy in normal and diseased liver},
  author={M. Czaja and W. Ding and T. Donohue and S. Friedman and Jae-Sung Kim and M. Komatsu and J. Lemasters and A. Lemoine and J. Lin and J. Ou and D. Perlmutter and G. Randall and R. Ray and A. Tsung and X. Yin},
  journal={Autophagy},
  year={2013},
  volume={9},
  pages={1131 - 1158}
}
Autophagy has emerged as a critical lysosomal pathway that maintains cell function and survival through the degradation of cellular components such as organelles and proteins. Investigations specifically employing the liver or hepatocytes as experimental models have contributed significantly to our current knowledge of autophagic regulation and function. The diverse cellular functions of autophagy, along with unique features of the liver and its principal cell type the hepatocyte, suggest that… Expand
Diverse Functions of Autophagy in Liver Physiology and Liver Diseases
  • Po-Yuan Ke
  • Biology, Medicine
  • International journal of molecular sciences
  • 2019
TLDR
This review summarizes the current knowledge on the functions of autophagy in hepatic metabolism and the contribution of Autophagy to the pathophysiology of liver-related diseases and the impacts on the development and progression of liver diseases are discussed. Expand
Autophagy in liver diseases: Time for translation?
TLDR
An update is provided on the regulatory role of autophagy in various aspects of liver pathophysiology, describing the different strategies to manipulate autophagic flux in vivo and discussing the potential to modulate Autophagy as a therapeutic strategy in the context of liver diseases. Expand
Autophagy in liver diseases
TLDR
The fundamental functions of autophagy in the liver including new data on the regulation of Autophagy are described and the different consequences that activation or impairment ofautophagy may have in hepatocytes as opposed to Kupffer cells, sinusoidal endothelial cells or hepatic stellate cells are stressed. Expand
Complex Cell Type-Specific Roles of Autophagy in Liver Fibrosis and Cirrhosis
TLDR
In view of the functional effects of multiple cell types on the complex process of hepatic fibrogenesis, integrated approaches that consider the role of autophagy in each liver cell type should be a focus of future research. Expand
Emerging Roles of Impaired Autophagy in Fatty Liver Disease and Hepatocellular Carcinoma
TLDR
How impaired autophagy affects liver function and contributes to NAFLD, AFLD, and HCC progression is summarized and how recent discoveries could provide novel therapeutic opportunities to effectively treat these diseases are explored. Expand
New aspects of the development of liver diseases – with special regard to the role of autophagy and microRNA
TLDR
In HBV-infected livers, the microRNA pathways related to cell death, DNA damage, recombination and signal transduction were activated and microRNA-122 effects multiple important factors which regulate the lipid and carbohydrate metabolisms in human non-alcoholic fatty liver disease. Expand
Autophagy in Liver Homeostasis
TLDR
Mechanistic details on the diverse roles of autophagy are being revealed and these studies will provide new insights on how Autophagy functions could be modulated in pathophysiological conditions of liver diseases. Expand
Autophagy is a gatekeeper of hepatic differentiation and carcinogenesis by controlling the degradation of Yap
TLDR
It is shown that hepatocyte-specific loss of Atg7 in mice leads to decreased autophagic degradation of Yap and liver overgrowth, and this association in human liver cancer tissues is established, shedding new light on mechanisms of YAP degradation and the sequence of events that follow disruption of autophagy. Expand
Homeostatic Role of Autophagy in Hepatocytes.
TLDR
This review will discuss two aspects of the importance of autophagy in the liver: metabolic regulation in response to feeding and starvation, and pathological consequences in the absence ofAutophagy, and how this can be a model for the study of the relevant molecular mechanisms. Expand
Autophagy in macrophages regulates the inflammasome and protects against liver injury.
TLDR
This issue of the Journal of Hepatology, Ilyas et al. demonstrated that macrophage autophagy inhibited inflammasomemediated IL-1b generation and secretion to limit acute toxin-induced liver injury. Expand
...
1
2
3
4
5
...

References

SHOWING 1-10 OF 328 REFERENCES
The emerging role of autophagy in alcoholic liver disease
TLDR
This review summarizes the recent findings about the role and mechanisms of autophagy in alcoholic liver disease (ALD), and the possible intervention for treating ALD by modulating Autophagy. Expand
Autophagy protects cells from HCV-induced defects in lipid metabolism.
TLDR
The role of HCV-induced autophagy in lipid degradation in cells infected with the virus or replicons is investigated, and disruption of the autophagic process might contribute to development of steatosis in patients with HCV. Expand
Regulation of mammalian autophagy in physiology and pathophysiology.
TLDR
This review focuses on mammalian autophagy, and an overview of the understanding of its machinery and the signaling cascades that regulate it is given, and the possibility of autophagic upregulation as a therapeutic approach for various conditions is considered. Expand
Restoration of chaperone-mediated autophagy in aging liver improves cellular maintenance and hepatic function
TLDR
It is shown that CMA activity is maintained until advanced ages if the decrease in the receptor abundance is prevented and that preservation of autophagic activity is associated with lower intracellular accumulation of damaged proteins, better ability to handle protein damage and improved organ function. Expand
Autophagy and Cell Death
TLDR
The roles of macroautophagy in both prosurvival and prodeath have been identified and it seems that autophagy may, in fact, be a key regulator of both apoptosis and necrosis. Expand
Impaired autophagy: A mechanism of mitochondrial dysfunction in anoxic rat hepatocytes
TLDR
Calpain 2–mediated degradation of Atg7 and Beclin‐1 impairs mitochondrial autophagy, and this subsequently leads to MPT‐dependent hepatocyte death after A/R, which was reversed by nutrient depletion and adenoviral overexpression. Expand
Pancreatic cancers require autophagy for tumor growth.
TLDR
Inhibition of autophagy by genetic means or chloroquine treatment leads to robust tumor regression and prolonged survival in pancreatic cancer xenografts and genetic mouse models, and drugs that inactivate this process may have a unique clinical utility in treating pancreatic cancers and other malignancies with a similar dependence on Autophagy. Expand
Macroautophagy and chaperone‐mediated autophagy are required for hepatocyte resistance to oxidant stress
TLDR
Hepatocyte resistance to injury from menadione‐induced oxidative stress is mediated by distinct functions of both macroautophagy and CMA, indicating that impaired function of either form of autophagy may promote oxidant‐induced liver injury. Expand
A role for autophagy during hepatic stellate cell activation.
TLDR
The demonstration of partly inhibition of in vitro HSC activation after treatment with an autophagy inhibitor unveils a potential new therapeutic strategy for liver fibrosis. Expand
Hepatic steatosis inhibits autophagic proteolysis via impairment of autophagosomal acidification and cathepsin expression.
TLDR
It is demonstrated that hepatic steatosis impairs autophagic proteolysis via impairment of autophagosomal acidification and cathepsin expression in hepatocytes from ob/ob mice. Expand
...
1
2
3
4
5
...