Functions of RANKL/RANK/OPG in bone modeling and remodeling.

  title={Functions of RANKL/RANK/OPG in bone modeling and remodeling.},
  author={Brendan F. Boyce and Lianping Xing},
  journal={Archives of biochemistry and biophysics},
  volume={473 2},
The discovery of the RANKL/RANK/OPG system in the mid 1990s for the regulation of bone resorption has led to major advances in our understanding of how bone modeling and remodeling are regulated. It had been known for many years before this discovery that osteoblastic stromal cells regulated osteoclast formation, but it had not been anticipated that they would do this through expression of members of the TNF superfamily: receptor activator of NF-kappaB ligand (RANKL) and osteoprotegerin (OPG… CONTINUE READING
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