Functions of Huntingtin in Germ Layer Specification and Organogenesis

  title={Functions of Huntingtin in Germ Layer Specification and Organogenesis},
  author={Giang D. Nguyen and Aldrin E. Molero and Solen Gokhan and Mark F. Mehler},
  booktitle={PloS one},
Huntington's disease (HD) is a neurodegenerative disease caused by abnormal polyglutamine expansion in the huntingtin protein (Htt). Although both Htt and the HD pathogenic mutation (mHtt) are implicated in early developmental events, their individual involvement has not been adequately explored. In order to better define the developmental functions and pathological consequences of the normal and mutant proteins, respectively, we employed embryonic stem cell (ESC) expansion, differentiation and… CONTINUE READING
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