Functions of Fibroblast Growth Factor Receptors in cancer defined by novel translocations and mutations.

@article{Gallo2015FunctionsOF,
  title={Functions of Fibroblast Growth Factor Receptors in cancer defined by novel translocations and mutations.},
  author={Leandro H. Gallo and Katelyn N Nelson and April N. Meyer and Daniel J. Donoghue},
  journal={Cytokine & growth factor reviews},
  year={2015},
  volume={26 4},
  pages={425-49}
}
The four receptor tyrosine kinases (RTKs) within the family of Fibroblast Growth Factor Receptors (FGFRs) are critical for normal development but also play an enormous role in oncogenesis. Mutations and/or abnormal expression often lead to constitutive dimerization and kinase activation of FGFRs, and represent the primary mechanism for aberrant signaling. Sequencing of human tumors has revealed a plethora of somatic mutations in FGFRs that are frequently identical to germline mutations in… CONTINUE READING
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