Functions of FGF signalling from the apical ectodermal ridge in limb development

@article{Sun2002FunctionsOF,
  title={Functions of FGF signalling from the apical ectodermal ridge in limb development},
  author={Xin Sun and Francesca V. Mariani and Gail Roberta Martin},
  journal={Nature},
  year={2002},
  volume={418},
  pages={501-508}
}
To determine the role of fibroblast growth factor (FGF) signalling from the apical ectodermal ridge (AER), we inactivated Fgf4 and Fgf8 in AER cells or their precursors at different stages of mouse limb development. We show that FGF4 and FGF8 regulate cell number in the nascent limb bud and are required for survival of cells located far from the AER. On the basis of the skeletal phenotypes observed, we conclude that these functions are essential to ensure that sufficient progenitor cells are… 
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