Functions of Chondroitin Sulfate/Dermatan Sulfate Chains in Brain Development

  title={Functions of Chondroitin Sulfate/Dermatan Sulfate Chains in Brain Development},
  author={Anurag Purushothaman and Junko Fukuda and Shuji Mizumoto and Gerdy B. ten Dam and Toin H. van Kuppevelt and Hiroshi Kitagawa and Tadahisa Mikami and Kazuyuki Sugahara},
  journal={Journal of Biological Chemistry},
  pages={19442 - 19452}
Chondroitin sulfate (CS) and dermatan sulfate (DS) have been implicated in the processes of neural development in the brain. In this study, we characterized developmentally regulated brain CS/DS chains using a single chain antibody, GD3G7, produced by the phage display technique. Evaluation of the specificity of GD3G7 toward various glycosaminoglycan preparations showed that this antibody specifically reacted with squid CS-E (rich in the GlcUAβ1–3GalNAc(4,6-O-sulfate) disaccharide unit E… 

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