Functions for Sterols in Yeast Membranes

  title={Functions for Sterols in Yeast Membranes},
  author={L. Parks and R. Lorenz and W. Casey},
  • L. Parks, R. Lorenz, W. Casey
  • Published 1992
  • Chemistry
  • Most of the clinically useful antifungal agents either interact directly with the sterols in the fungal membrane or interfere with the synthesis of fungal sterols. The characteristics of these agents have been studied extensively in recent years, but their precise mechanisms in altering fungal growth are only poorly understood. Our research on Saccharomyces cerevisiae has produced evidence that there are multiple functions for sterols in this organism. It seems logical that such is the case for… CONTINUE READING
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    • PDF
    Antifungals: mechanism of action and resistance, established and novel drugs.
    • 196
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    • 425
    • PDF


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    • 145
    The functional importance of structural features of ergosterol in yeast.
    • 134
    • PDF
    Stereochemically distinct roles for sterol in Saccharomyces cerevisiae.
    • 49
    Sterol synergism in yeast.
    • M. Ramgopal, K. Bloch
    • Biology, Medicine
    • Proceedings of the National Academy of Sciences of the United States of America
    • 1983
    • 77
    • PDF
    Multiple functions for sterols in Saccharomyces cerevisiae.
    • 233
    Homoazasterol-mediated inhibition of yeast sterol biosynthesis.
    • 28